TRIUMPH is the most under-discussed thing on this board
TRIUMPH is the most under-discussed thing on this board. Making the case below, and I expect to lose some of it in the comments. Stopped at a low step because there was no reason to go further and no data to tell me what further would do. The thing that surprised me was how much of the discussion here is inference…
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.
dose escalation in the trials was slow for a reason
dose escalation in the trials was slow for a reason
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
honest_syringe33 is right about the escalation being the variable. It explains most of the difficult reports here.
This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.
Are you comparing against phase 3 numbers for something else? They are not comparable.