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c/retatrutide·submitted 2 months ago by u/deleted_my_history

anyone else notice glucagon kicking in around week 51

Cautionbranch of 11 comments

Check-in as promised in the title: anyone else notice glucagon kicking in around week 51. Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer. Independent purity testing on this compound is thin…

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11 comments, started 2 months ago
u/yara_lindholm131 points·2 months ago

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

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u/trialwatch_theotrial nerd56 points·2 months ago

Agreed, and the framing that helps is: this is a phase 2 compound with phase 3 running. Everything else is inference.

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u/nabila_bakken39 points·2 months ago

Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.

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u/cold_chromatogram_only11 points·2 months ago

not approved anywhere, which is the single most important fact in this board

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u/careful_gradient329 points·2 months ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/emil_wojcik13 points·2 months ago

a lot of the confident posting here is extrapolation

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u/trialwatch_theotrial nerd66 points·2 months ago

The early fullness profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

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u/viktor_laurent53 points·2 months ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/reta_and_regretMOD87 points·2 months ago

Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.

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u/deleted_my_historyOP67 points·2 months ago

the glucagon component is why the metabolic story reads differently

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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