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Single comment threadYou are looking at one branch of genuine question about retatrutide that I am slightly embarrassed to ask — 46 comments in the full submission. View in context.
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c/retatrutide·submitted 4 months ago by u/signe_villalobos

genuine question about retatrutide that I am slightly embarrassed to ask

Labbranch of 6 comments

genuine question about retatrutide that I am slightly embarrassed to ask. Searched first, found three threads that contradict each other, hence the post. The thing that surprised me was how much of the discussion here is inference rather than measurement. Watched heart rate on a wearable across twelve weeks because…

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6 comments, started 4 months ago
u/niels_lindqvist297 points·4 months ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/yannick_barros238 points·4 months ago

Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.

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u/cold_chromatogram_only0 points·4 months ago

The injection-site soreness profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

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u/signe_villalobosOP-13 points·4 months ago

The injection-site soreness profile felt different rather than worse.

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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u/lina_bruun1 point·4 months ago

Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.

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u/sena_teixeira1 point·4 months ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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