what changed for me between month 10 and month 14
The title is the whole question — what changed for me between month 10 and month 14 — but here is why I am asking.
Kept a log specifically because there is so little published. It is one person and it is not data.
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
Trial names corrected in the title. The phase 3 programme and the phase 2 readout are not the same thing.
Where the evidence actually stands, since every thread here assumes a different answer.
Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.
Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.
Are you comparing against phase 3 numbers for something else? They are not comparable.
comparing reta phase 2 to sema phase 3 is comparing different things
a lot of the confident posting here is extrapolation
The thing that surprised me was how much of the discussion here is inference rather than measurement.