[Discussion] can we stop arguing about dose escalation until somebody posts a number
can we stop arguing about dose escalation until somebody posts a number. Searched first, found three threads that contradict each other, hence the post. Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a…
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
the energy-expenditure story is mechanistically interesting and clinically unproven
Not convinced. You are attributing a week of sulphur burps to the glucagon arm when the escalation rate alone would explain it.
Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
heart rate is the thing people report watching