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c/retatrutide·submitted 8 months ago by u/placebo_arm_pam

[Discussion] phase 2 is doing more work than we give it credit for

Discussionbranch of 7 comments

phase 2 is doing more work than we give it credit for. Change my mind, genuinely — I have no stake in being right about this. The standing caveat, written out properly because it keeps getting compressed into a footnote. Nothing containing this compound is approved by any regulator. Research-use-only material is not…

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7 comments, started 8 months ago
u/halima_mbeki12 points·8 months ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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u/nabila_bakken17 points·8 months ago·edited

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/incretin_ivyMOD9 points·8 months ago·edited

Left up. It reads the phase 2 paper carefully and it is honest about the intervals.

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u/marta_vanhecke10 points·8 months ago

small trial, big effect, wide error bars

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u/two_mil_or_one7 points·8 months ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/placebo_arm_pamOP9 points·8 months ago

What is the source for that figure — the published paper or a summary of it?

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u/helga_vermeulen13 points·8 months ago·edited

Which phase 2 arm are you quoting, and at what week?

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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