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c/retatrutide·submitted 23 days ago by u/trialwatch_theo

is it normal to get muscle cramps at week 85

Discussionbranch of 10 comments

is it normal to get muscle cramps at week 85. Same spreadsheet I have been keeping since the start, nothing retrofitted. Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is…

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10 comments, started 22 days ago
u/source_or_silence12 points·22 days ago

That reads as a titration plan for an unapproved compound. This board cannot host that and it should not want to.

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u/two_mil_or_one3 points·22 days ago

dose escalation in the trials was slow for a reason

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u/farid_molnar1 point·21 days ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/quiet_moderatormod1 point·21 days ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/lurker_for_years3 points·22 days ago

Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.

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u/bastian_ekstrom2 points·21 days ago

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.

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u/deleted_my_history1 point·21 days ago·edited

Nothing containing this compound is approved anywhere.

Agreed, and the glucagon arm is exactly why the comparison threads do not work.

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u/yara_lindholm1 point·21 days ago

not approved anywhere, which is the single most important fact in this board

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[deleted]5 points·22 days ago

[deleted]

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u/crosspost_bot_no4 points·21 days ago

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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