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c/retatrutide·submitted 2 years ago by u/trialwatch_theo

[Lab] 2th independent test on BCH — 97.8% on a claimed 97.5%, and the trend is the interesting part

Labbranch of 11 comments

Title says it — 2th independent test on BCH — 97.8% on a claimed 97.5%, and the trend is the interesting part — so here is the boring supporting detail that makes it worth anything. The relevant figures are 97.8% and 97.5%, and they come from the same log I have kept the whole time. Watched heart rate on a wearable…

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11 comments, started 2 years ago
u/incretin_ivyMOD1.3k points·2 years ago

Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.

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[deleted]898 points·2 years ago

[deleted]

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u/helga_vermeulen510 points·2 years ago

The injection-site soreness profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

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u/kofi_balogun845 points·2 years ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/trialwatch_theoOPtrial nerd376 points·2 years ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/trialwatch_theoOPtrial nerd666 points·2 years ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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u/careful_gradient_notes461 points·2 years ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/cagrilintide_enthusiast387 points·2 years ago

Where the evidence actually stands, since every thread here assumes a different answer.

Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.

Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.

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u/trialwatch_theoOPtrial nerd302 points·2 years ago

That is body weight change, not fat mass. The trials report the first and people quote it as the second.

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u/ismael_eriksen92 points·2 years ago

research-use-only material is not approved for human use, full stop

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u/discount_math_dm249 points·2 years ago

a lot of the confident posting here is extrapolation

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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