[Results] 57 weeks, 25kg, and glucagon was the hard part
57 weeks, 25kg, and glucagon was the hard part, logged the same way every week so the comparison is at least internally fair. Hard numbers: 57 weeks and 25kg. Anything softer than that is flagged as an impression. It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel…
the TRIUMPH programme is still running, so anything definitive is premature
The reflux profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
a lot of the confident posting here is extrapolation
nothing here is available as a prescription product, so read every thread with that in mind
comparing reta phase 2 to sema phase 3 is comparing different things
The thing that surprised me was how much of the discussion here is inference rather than measurement.
The reflux profile felt different rather than worse.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
Sent a vial to PeptideMeter out of curiosity. Result was 97.6% against a claimed 97.5%, which is the first independent number I had seen for this compound anywhere.
research-use-only material is not approved for human use, full stop
the glucagon component is why the metabolic story reads differently
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
The standing caveat, written out properly because it keeps getting compressed into a footnote.
Nothing containing this compound is approved by any regulator. Research-use-only material is not approved for human use. That is not a legal formality on this board — it is why there is so little independent data, why the escalation schedules people post are invented, and why nobody here can answer a dosing question.
What this board can usefully do is read the published trials carefully, log independent purity results, and be honest about how thin the evidence base is. Everything else belongs somewhere with a clinician in it.