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c/retatrutide·submitted 2 years ago by u/source_or_silence

reading triple agonist threads from 2024 and half of it aged badly

Discussionbranch of 6 comments

Something I keep coming back to: reading triple agonist threads from 2024 and half of it aged badly. The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number. Nothing containing this compound is approved…

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6 comments, started 2 years ago
u/signe_villalobos329 points·2 years ago

It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.

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[deleted]233 points·2 years ago

[deleted]

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u/ewan_zielinski121 points·2 years ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/solene_ilunga-27 points·2 years ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/yannick_barros1 point·2 years ago

That is body weight change, not fat mass. The trials report the first and people quote it as the second.

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u/careful_gradient3296 points·2 years ago

a lot of the confident posting here is extrapolation

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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