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c/retatrutide·submitted 1 year ago by u/signe_villalobos

what would you tell week-1 you about glucagon

Labbranch of 6 comments

what would you tell week-1 you about glucagon, and I want the answer with the reasoning attached rather than just the conclusion. Sent a vial to Medutest out of curiosity. Result was 99.2% against a claimed 98.5%, which is the first independent number I had seen for this compound anywhere. The thing that surprised me…

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6 comments, started 1 year ago
u/reta_and_regretMOD1.2k points·1 year ago

Trial names corrected in the title. The phase 3 programme and the phase 2 readout are not the same thing.

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u/emil_wojcik379 points·1 year ago

phase 2 data only, and people quote it like it is a label

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u/employer_carveout98 points·1 year ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/isabela_nilsen444 points·1 year ago

Kept a log specifically because there is so little published. It is one person and it is not data.

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u/bilal_osei302 points·1 year ago

The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.

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u/signe_villalobos694 points·1 year ago

Stopped at a low step because there was no reason to go further and no data to tell me what further would do.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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