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c/retatrutide·submitted 26 days ago by u/cold_chromatogram_only

[Discussion] glucagon is doing more work than we give it credit for

Discussionbranch of 6 comments

glucagon is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.…

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6 comments, started 25 days ago
u/incretin_ivyMOD66 points·25 days ago

Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.

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u/yannick_barros52 points·25 days ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/lurker_for_years-12 points·25 days ago

the escalation is where most of the reported trouble sits

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u/ferran_krastev1 point·25 days ago

a lot of the confident posting here is extrapolation

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u/two_mil_or_one28 points·25 days ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/janek_ferrari41 points·25 days ago

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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