5 months in and dose escalation is still the thing I get wrong
5 months in and dose escalation is still the thing I get wrong. Same spreadsheet I have been keeping since the start, nothing retrofitted. Numbers, in the order they matter: 5 months. Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am…
Left up. It reads the phase 2 paper carefully and it is honest about the intervals.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
Push back: quoting the phase 2 headline as an expected outcome is not a fair reading of a small trial with wide intervals.
Correction: TRIUMPH is the phase 3 programme.
This is the sentence the rest of the board should read first. Phase 2 is not a label.
Which phase 2 arm are you quoting, and at what week?
Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.
That is body weight change, not fat mass. The trials report the first and people quote it as the second.
heart rate is the thing people report watching
the phase 2 numbers were striking and they were also 48 weeks in a small population
The thing that surprised me was how much of the discussion here is inference rather than measurement.
the escalation is where most of the reported trouble sits
comparing reta phase 2 to sema phase 3 is comparing different things