stalled for 11 weeks at 12.5mg and I refuse to panic this time
stalled for 11 weeks at 12.5mg and I refuse to panic this time, and I am aware this is a minority view on this board. The relevant figures are 11 weeks and 12.5mg, and they come from the same log I have kept the whole time. Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger…
The injection-site soreness profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
phase 2 data only, and people quote it like it is a label
Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
comparing reta phase 2 to sema phase 3 is comparing different things
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.