TRIUMPH — 16 things I got wrong before I got it right
Posting this as a discussion rather than a claim: TRIUMPH — 16 things I got wrong before I got it right. What the glucagon arm is doing, as best anyone can say from public data. GLP-1 and GIP agonism cover appetite and insulin secretion in ways that are now reasonably well characterised. Glucagon receptor agonism is…
The standing caveat, written out properly because it keeps getting compressed into a footnote.
Nothing containing this compound is approved by any regulator. Research-use-only material is not approved for human use. That is not a legal formality on this board — it is why there is so little independent data, why the escalation schedules people post are invented, and why nobody here can answer a dosing question.
What this board can usefully do is read the published trials carefully, log independent purity results, and be honest about how thin the evidence base is. Everything else belongs somewhere with a clinician in it.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
the glucagon component is why the metabolic story reads differently
Watched heart rate on a wearable across twelve weeks because the threads said to.
This is the sentence the rest of the board should read first. Phase 2 is not a label.
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.
Is that the 48-week figure or an earlier readout?
Are you comparing against phase 3 numbers for something else? They are not comparable.