[Discussion] we are measuring TRIUMPH at the wrong time and calling it noise
we are measuring TRIUMPH at the wrong time and calling it noise. Making the case below, and I expect to lose some of it in the comments. The constipation profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression. Independent purity testing on this compound is…
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
Cosigning the escalation point.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
a lot of the confident posting here is extrapolation
research-use-only material is not approved for human use, full stop
Not convinced. You are attributing a week of nausea to the glucagon arm when the escalation rate alone would explain it.
Not convinced.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
That is body weight change, not fat mass. The trials report the first and people quote it as the second.
That is body weight change, not fat mass.
tired_ledger_notes is right about the escalation being the variable. It explains most of the difficult reports here.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
Kept a log specifically because there is so little published. It is one person and it is not data.
Not convinced.
This is the sentence the rest of the board should read first. Phase 2 is not a label.