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c/retatrutide·submitted 5 days ago by u/source_or_silence

the glucagon arm is why the appetite effect feels different

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the glucagon arm is why the appetite effect feels different — a position I have arrived at slowly and would like tested. Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything. The thing that surprised me was how much of the…

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6 comments, started 4 days ago
u/halima_mbeki104 points·4 days ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/customs_seizure_sid29 points·4 days ago

Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.

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u/jarno_cabrera86 points·4 days ago

What is the source for that figure — the published paper or a summary of it?

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u/bastian_ekstrom36 points·3 days ago

It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.

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u/source_or_silenceOP20 points·3 days ago

Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.

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u/yannick_salinas9 points·3 days ago

comparing reta phase 2 to sema phase 3 is comparing different things

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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