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c/retatrutide·submitted 4 days ago by u/liver_enzyme_liz

[Lab] two reta batches, two services, 98.4% and 97.9%

Labbranch of 8 comments

two reta batches, two services, 98.4% and 97.9%, and before anyone asks: same batch throughout, single submission, no cherry-picking between services. 98.4% and 97.9%. Those are measured, not estimated, and not rounded up in my favour. Stopped at a low step because there was no reason to go further and no data to…

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8 comments, started 3 days ago
u/lina_bruun108 points·3 days ago

Is that the 48-week figure or an earlier readout?

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u/liver_enzyme_lizOP39 points·2 days ago

dose escalation in the trials was slow for a reason

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u/lane_watchermod · logistics10 points·2 days ago

What is the source for that figure — the published paper or a summary of it?

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u/fabio_lehtinen8 points·2 days ago·edited

That is body weight change, not fat mass. The trials report the first and people quote it as the second.

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u/liver_enzyme_lizOP-6 points·1 days ago

Has anyone posted an independent test on this compound recently?

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u/priya_weiss51 points·2 days ago

Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.

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u/liver_enzyme_lizOP29 points·2 days ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/ewan_marchand40 points·2 days ago

the phase 2 numbers were striking and they were also 48 weeks in a small population

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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