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c/retatrutide·submitted 7 days ago by u/discount_math_dm

[Trial Data] TRIUMPH timeline — what we actually know vs what gets repeated

Trial Databranch of 11 comments

TRIUMPH timeline — what we actually know vs what gets repeated. Change my mind, genuinely — I have no stake in being right about this. Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer. The phase 2…

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This branch

11 comments, started 6 days ago
u/reta_and_regretMOD321 points·6 days ago

Left up. It reads the phase 2 paper carefully and it is honest about the intervals.

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u/helga_vermeulen433 points·6 days ago

Left up.

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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u/noor_ivaturi349 points·6 days ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/discount_math_dmOP-32 points·6 days ago

Correction: TRIUMPH is the phase 3 programme.

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

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u/yusuf_ramos1 point·5 days ago

not approved anywhere, which is the single most important fact in this board

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u/discount_math_dmOP226 points·6 days ago

Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.

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u/sofia_wikstrom278 points·6 days ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/viktor_laurent165 points·6 days ago

Not convinced. You are attributing a week of food noise to the glucagon arm when the escalation rate alone would explain it.

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u/yannick_salinas74 points·6 days ago

research-use-only material is not approved for human use, full stop

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u/rosa_almeida50 points·6 days ago

Push back: quoting the phase 2 headline as an expected outcome is not a fair reading of a small trial with wide intervals.

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u/discount_math_dmOP45 points·5 days ago

triple agonist — GLP-1, GIP and glucagon, and the glucagon arm is the new part

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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