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c/retatrutide·submitted 1 year ago by u/viktor_laurent

dose escalation — my 16-week log, condensed into one table

Questionbranch of 7 comments

The title is the argument: dose escalation — my 16-week log, condensed into one table. Here is the rest of it. It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it. The standing caveat, written…

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7 comments, started 1 year ago
u/hugo_pires184 points·1 year ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/ferran_krastev269 points·1 year ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/blunt_coldbox_202460 points·1 year ago

The thing that surprised me was how much of the discussion here is inference rather than measurement.

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u/cold_chromatogram_only0 points·1 year ago

the TRIUMPH programme is still running, so anything definitive is premature

Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.

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u/honest_syringe331 point·1 year ago

the glucagon component is why the metabolic story reads differently

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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