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c/retatrutide·submitted 9 months ago by u/careful_gradient_notes

week 32 check-in — 14kg down, nausea manageable, one thing confusing me

Resultsbranch of 7 comments

week 32 check-in — 14kg down, nausea manageable, one thing confusing me, and the part I actually want to talk about is at the bottom. Numbers, in the order they matter: week 32 and 14kg. Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a…

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7 comments, started 9 months ago
u/hassan_nilsen111 points·9 months ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/cagrilintide_enthusiast93 points·9 months ago

Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.

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u/hassan_nilsen25 points·9 months ago

Are you comparing against phase 3 numbers for something else? They are not comparable.

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u/careful_gradient_notesOP-22 points·9 months ago

Has anyone posted an independent test on this compound recently?

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u/careful_gradient_notesOP1 point·9 months ago

Are you tracking heart rate at all?

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u/baseline_drifteranalytical110 points·9 months ago

Kept a log specifically because there is so little published. It is one person and it is not data.

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u/nikhil_lindqvist59 points·9 months ago

Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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