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c/retatrutide·submitted 2 years ago by u/andres_sorensen

unpopular opinion: most of what gets said here about glucagon is guesswork

Trial Databranch of 7 comments

unpopular opinion: most of what gets said here about glucagon is guesswork, and I am aware this is a minority view on this board. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with…

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This branch

7 comments, started 2 years ago
u/cagrilintide_enthusiast140 points·2 years ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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u/endotoxin_elliemicro97 points·2 years ago

Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.

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u/careful_gradient_notes166 points·2 years ago

dose escalation in the trials was slow for a reason

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u/ismael_eriksen36 points·2 years ago

research-use-only material is not approved for human use, full stop

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u/hassan_nilsen11 points·2 years ago

the glucagon component is why the metabolic story reads differently

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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