unpopular opinion: most of what gets said here about glucagon is guesswork
unpopular opinion: most of what gets said here about glucagon is guesswork, and I am aware this is a minority view on this board. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with…
The constipation profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.
phase 2 data only, and people quote it like it is a label
Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.
Is that the 48-week figure or an earlier readout?
Has anyone posted an independent test on this compound recently?
Which phase 2 arm are you quoting, and at what week?
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.