is it normal to get sulphur burps at week 24
is it normal to get sulphur burps at week 24. Full detail below, and I have tried to keep the editorialising out of it.
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
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Is that the 48-week figure or an earlier readout?
Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.
phase 2 data only, and people quote it like it is a label
phase 2 data only, and people quote it like it is a label
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
This is the sentence the rest of the board should read first. Phase 2 is not a label.
Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
Has anyone posted an independent test on this compound recently?
Has anyone posted an independent test on this compound recently?
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
wait for phase 3 before you argue about rankings
comparing reta phase 2 to sema phase 3 is comparing different things
Sent a vial to Janoshik out of curiosity. Result was 98.4% against a claimed 97.5%, which is the first independent number I had seen for this compound anywhere.
Sent a vial to Janoshik out of curiosity.
discount_math_dm is right about the escalation being the variable. It explains most of the difficult reports here.
Trial names corrected in the title. The phase 3 programme and the phase 2 readout are not the same thing.
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.
Kept a log specifically because there is so little published. It is one person and it is not data.
Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.
Cosigning the escalation point.
Agreed, and the glucagon arm is exactly why the comparison threads do not work.
Push back: quoting the phase 2 headline as an expected outcome is not a fair reading of a small trial with wide intervals.
heart rate is the thing people report watching
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.
Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.
Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.
the glucagon component is why the metabolic story reads differently
How fast was the escalation? That is usually the variable that explains the reports.
the TRIUMPH programme is still running, so anything definitive is premature
Agreed, and the framing that helps is: this is a phase 2 compound with phase 3 running. Everything else is inference.
- 1Phase 2 estimates effect and finds a dose range. Phase 3 estimates it…8 comments in this branch · started by u/nabila_bakken
- 2Has anyone posted an independent test on this compound recently?7 comments in this branch · started by u/kavya_kravchenko