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c/reconstitution·submitted 1 year ago by u/santiago_ndiaye

do units actually matter or is it forum lore at this point

Questionbranch of 7 comments

Asking properly rather than in a comment on somebody else’s thread: do units actually matter or is it forum lore at this point. Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful. Reconstituted at…

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7 comments, started 1 year ago
u/alcohol_aversion124 points·1 year ago

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

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u/marta_weiss58 points·1 year ago

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

This is the sentence that makes the rest unnecessary. Write it on the vial and the problem is gone.

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u/yusuf_achebe85 points·1 year ago

a U-100 syringe reads 100 units to the millilitre, every time

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u/declared_value_dv23 points·1 year ago

the powder cake sits at the bottom, the volume you add is the volume that counts

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u/santiago_ndiayeOP18 points·1 year ago

the powder cake sits at the bottom, the volume you add is the volume that counts

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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u/ilias_cabrera21 points·1 year ago

if the maths gives you a fraction of a unit, change the concentration

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u/swirl_dont_shakereconstitution39 points·1 year ago

Pushback on the syringe advice: a U-100 barrel reads units of volume. Calling them "doses" is how the confusion starts.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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