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[Meta] proposal — a flair for lowest effective dose posts

Meta

proposal — a flair for lowest effective dose posts. Short post, long comment section, probably.

Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline.

Body weight varies by a couple of kilos over days in stable people through fluid, glycogen and gut content. A range is not a trend.

Dose reduction and interval extension are different interventions. Halving the dose keeps the rhythm and lowers the level; stretching keeps the level and lowers the frequency, with a lower trough.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

144 up / 47 down75% upvoted12 commentsid qzasch17 Mar 2026

12 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/kaplan_meier_kim12 points·4 months ago

What maintenance actually looks like, from the people on this board who have been in it longest.

You find a dose or an interval that holds the weight with side effects you barely notice, and then you stop optimising. Weigh monthly rather than daily. Expect a couple of kilos of range and do not act on it. Keep the habits that did the work in the losing phase, because they are the part that has to outlive the dose.

The most common mistake described here is treating arrival as a plateau and pushing the dose to chase a number chosen at week one by a person who did not yet know what maintenance felt like.

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u/teodor_duarte10 points·4 months ago

What maintenance actually looks like, from the people on this board who have been in it longest.

Agreed — and appetite is the leading indicator. The scale is the lagging one.

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u/ferritin_low11 points·4 months ago

Not convinced. Interval stretching changes your exposure profile, not just the total, and the two are not equivalent.

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[deleted]4 points·4 months ago

[deleted]

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u/enzo_danquah7 points·4 months ago

Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.

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u/nnt_nate5 points·4 months ago·edited

I would not treat a two-kilo range as drift requiring action. That is ordinary weight variation.

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u/adnan_sandvik6 points·4 months ago

the lowest effective dose is a real target and nobody talks about it

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u/priya_weiss3 points·4 months ago

the lowest effective dose is a real target and nobody talks about it

This reframing is the most useful thing on the board for anyone approaching this phase.

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u/column_dead_volumeOP5 points·4 months ago

What does your weigh-in frequency look like at this point?

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u/column_dead_volumeOP0 points·4 months ago

What dose are you holding, and for how long now?

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u/britt_abubakar4 points·4 months ago

Appetite returning before the scale moves follows from the mechanism: the appetite effect is the proximal one and weight is the lagging integrated outcome.

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u/fatima_asante1 point·4 months ago

Chased the last three kilos with a dose increase and got a fortnight of food noise and no change in the number.

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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