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c/coldchain·posted 2 years ago by u/zeynep_ndiaye

[Question] Australia — has anyone got a straight answer on lyophilised

Question

Australia — has anyone got a straight answer on lyophilised — that is what I am asking, and I have already read the wiki twice.

Regional stock changes the question rather than answering it: shorter lanes mean less exposure and fewer variables, which is why the warehouse question is worth asking before ordering in summer.

You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material.

Put a logger in three consecutive orders. Two never went above the range at all and the third spent four hours warm on a Friday. Cost me almost nothing to stop wondering.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

0 up / 0 down50% upvoted8 commentsid ribyva15 Feb 2024

8 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/zeynep_ndiaye1 point·2 years ago

Gel packs are designed for a duty cycle. A liquid pack at the end of a longer-than-expected transit is a pack behaving as specified, not evidence of an excursion in the vial.

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[removed]1 point·2 years ago

[removed by moderator]

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u/ewan_tulloch1 point·2 years ago

Asked GL Biochem which lines they hold regionally and got a straight list back. That answered my summer ordering question completely.

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u/noor_cardoso1 point·2 years ago

Small fix — refrigerated, not frozen, once it is in solution.

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u/gustav_vermeulen1 point·2 years ago

the excursion that matters is the one after reconstitution

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u/source_or_silence1 point·2 years ago

Correction: that stability figure covers the lyophilised powder, not the reconstituted solution. Different claim entirely.

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u/vito_chowdhury1 point·2 years ago

Lyophilisation removes the water that drives most degradation pathways. That is why the dry cake is comparatively robust and the reconstituted solution is not.

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u/bastian_ekstrom1 point·2 years ago

Agreed. The dry powder is the robust state; it is the solution that needs the care.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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