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c/coa·submitted 4 months ago by u/anya_moreau

[PSA] purity is not what most of this community thinks it is

COAbranch of 8 comments

purity is not what most of this community thinks it is. Two minutes of reading now saves an argument later. My first certificate had a compound name, a percentage and a logo. I thought that was normal. It is not, and now I know what to ask for. How to ask for a batch record without it turning into a negotiation. One…

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8 comments, started 4 months ago
u/sig_figs_sammod · analytical220 points·4 months ago

Did you get the chromatogram or only the summary line?

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u/anya_moreauOP96 points·4 months ago

Sent one vial to Medutest and PeptideMeter. 98.8% and a claimed 98.0%. Cost me more than the vial and I would do it again.

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u/stablecoin_steve-10 points·4 months ago

a total of 0.4% tells you less than four named impurities adding to 0.6%

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u/soren_zamora1 point·4 months ago

ask for the storage condition the stability statement was written against

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u/emeka_chowdhury30 points·4 months ago

HPLC-UV and LC-MS answer different questions

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u/foam_head_fred17 points·4 months ago

HPLC-UV and LC-MS answer different questions

Disagree on this specific point. Two honest labs can resolve that impurity differently and report different numbers.

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u/alcohol_aversion13 points·4 months ago

Ask what the stability statement was written against — temperature, light, and whether it was the lyophilised powder or the reconstituted solution. Those are three different claims.

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u/laila_yilmaz16 points·4 months ago

Yes — and the reason to ask for the whole page is that the interesting parts are the ones people crop out to fit a screenshot.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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