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u/coa_collector

I have 1,100 COAs in a folder structure that would frighten you. Ask before you order.

long-standing contributor · archivist · joined 12 Sep 2023

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comment on why is the sequence written four different ways across four vendor sites in c/researchpeptides · 74 points · 1 days ago

same list as the water-content one, which is not a coincidence.

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comment on WXT and BCH put water content on the COA when nobody asks for it, and i think that is the tell in c/vendorvetting · 58 points · 2 days ago

agreed and that is a fair check on my argument. correlation not causation, n of about eight vendors. edit: SWB sits at 96% on our own directory, which is roughly where the material says it should be, so the community has already priced this in.

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comment on WXT and BCH put water content on the COA when nobody asks for it, and i think that is the tell in c/vendorvetting · 201 points · 2 days ago

this is the bit i should have led with instead of burying it in paragraph three. fixing that in my head for next time.

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comment on net peptide content: i finally have a number and almost nothing to compare it against in c/scamalerts · 94 points · 3 days ago

one in eight of my documents have it. if a hundred people asked on every order it would be standard inside a year.

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comment on net peptide content vs purity — two different numbers, same vial, and only one is on your COA in c/coa · 81 points · 4 days ago

the collective-nagging mechanism is genuinely the most effective tool this community has and it never gets written up as one.

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comment on net peptide content vs purity — two different numbers, same vial, and only one is on your COA in c/coa · 288 points · 5 days ago

One in eight across my folder, and it clusters hard by vendor. WXT and BCH have it most of the time. Everyone else, rarely, and usually only when somebody asked.

Which tells you the assay is not hard or expensive — it tells you it is not demanded. If a hundred people asked for it on every order it would be on every document inside a year.

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comment on which fields turn a COA from a specification into a result in c/coa · 15 points · 7 days ago

Left up and flaired Explainer. This is the answer we keep linking, written properly.

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comment on [Suspicious] identical chromatogram on two different compounds from the same vendor in c/coa · 345 points · 9 days ago

Does the lot on the vial match the lot on the page?

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comment on water content is on the COA and everyone skips it in c/coa · 30 points · 9 days ago

Removed — cropped document. Post the whole page or do not post it; the fields people crop are the fields that matter.

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comment on [COA] what does "related substances 1.4%" actually mean for my vial in c/coa · 2 points · 10 days ago

the related substances line is where the story is

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comment on [Question] vendor COA says 99.2%, my Janoshik came back 97.4%. who is wrong in c/coa · 1 points · 20 days ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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comment on [Suspicious] the same signature image on COAs from three vendors in c/coa · 1 points · 24 days ago

net peptide content and purity are two different numbers on the same vial

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comment on [PSA] batch is not what most of this community thinks it is in c/coa · 24 points · 1 months ago

HPLC-UV and LC-MS answer different questions

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comment on [Lab] 6th independent test on HJ — 99.1% on a claimed 99.0%, and the trend is the interesting part in c/coa · 197 points · 1 months ago

Left up and flaired Explainer. This is the answer we keep linking, written properly.

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comment on [Discussion] certificate of analysis is doing more work than we give it credit for in c/coa · 36 points · 1 months ago

the counterion is part of the mass you paid for

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comment on genuine question about area percent that I am slightly embarrassed to ask in c/coa · 88 points · 2 months ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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comment on help me understand COA, I have read the wiki twice in c/coa · 129 points · 2 months ago

Your name and address edited out of the screenshot above. The batch details are untouched and should stay.

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comment on someone explain stability to me like I have not read a paper in years in c/coldchain · 10 points · 2 months ago

A transit temperature logger records a distribution, and time above a threshold matters as much as peak temperature. That is the argument for logging rather than guessing.

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comment on reading certificate of analysis threads from 2024 and half of it aged badly in c/coa · 31 points · 3 months ago

Agreed — the itemised related substances table is the difference between a document and a receipt.

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comment on how much of what we believe about packaging actually comes from stability threads in c/coldchain · 47 points · 4 months ago

Correcting myself above: the transit was 4 days, not the figure I posted. Same conclusion, wrong number.

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comment on how much of what we believe about packaging actually comes from stability threads in c/coldchain · 3 points · 4 months ago

light matters more than people think for some of these

Disagreeing with this line only: freezing a reconstituted vial is not a safe default.

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comment on how much of what we believe about packaging actually comes from stability threads in c/coldchain · 2 points · 5 months ago

Powder or already in solution?

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comment on area percent — 13 things I got wrong before I got it right in c/coa · 151 points · 5 months ago

Ask what the stability statement was written against — temperature, light, and whether it was the lyophilised powder or the reconstituted solution. Those are three different claims.

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comment on Spain: cold chain, and what it actually costs here in c/coldchain · 0 points · 5 months ago

Ordered from the warehouse in Canada instead of origin and the transit went from a fortnight to 7 days. Entirely different proposition in August.

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comment on does purity actually matter or is it forum lore at this point in c/coa · 6 points · 6 months ago

area% is not mass%, and the difference is the whole game

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comment on does purity actually matter or is it forum lore at this point in c/coa · 117 points · 6 months ago

Left up and flaired Explainer. This is the answer we keep linking, written properly.

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comment on COA — 5 things I got wrong before I got it right in c/coa · 72 points · 6 months ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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comment on [Discussion] area percent is doing more work than we give it credit for in c/coa · 330 points · 8 months ago

How to ask for a batch record without it turning into a negotiation.

One email, three requests: the batch-specific certificate for lot X, the method line behind it, and the storage condition the stability statement was written against. No preamble, no explanation of why you want it.

What comes back is the signal. A full document with the column and gradient printed on it, inside a day, tells you there is a real quality system behind the operation. That is the test I run before I order from anyone new, and it costs nothing.

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comment on [Discussion] the packaging advice in here is 3 years out of date in c/coldchain · 2 points · 9 months ago

Small fix — refrigerated, not frozen, once it is in solution.

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comment on [Discussion] the packaging advice in here is 3 years out of date in c/coldchain · 10 points · 9 months ago

powder at room temperature for a few days is usually a non-event

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comment on [Discussion] the packaging advice in here is 3 years out of date in c/coldchain · 1 points · 9 months ago

if you want to know, log it, otherwise you are guessing

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comment on [Discussion] the packaging advice in here is 3 years out of date in c/coldchain · 10 points · 9 months ago

Correcting myself above: the transit was 10 days, not the figure I posted. Same conclusion, wrong number.

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comment on [Question] how do you actually verify data logger in c/coldchain · 202 points · 10 months ago

Seasonality, which the source-page lane tables show clearly once you look for it.

The same origin, destination and carrier can differ by several days between February and August, and the temperature exposure differs by much more than the transit time suggests. A lane that is uneventful in winter is the same lane that generates the summer threads.

Two practical consequences. First, compare like months when you compare lanes. Second, ask which lines a supplier holds in regional stock — a shorter leg in July is worth more than any amount of packaging.

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comment on [Discussion] can we stop arguing about water content until somebody posts a number in c/coa · 18 points · 10 months ago

Same view. Homopeptide prints the column and the gradient, which means somebody could actually reproduce the run.

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comment on [Discussion] can we stop arguing about water content until somebody posts a number in c/coa · 199 points · 10 months ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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comment on [Question] related substances — what am I missing here in c/coa · 277 points · 10 months ago

a total of 0.4% tells you less than four named impurities adding to 0.6%

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comment on [Question] batch — what am I missing here in c/coa · 93 points · 11 months ago

Careful — "the metadata looks odd" is a reason to ask a question, not a conclusion. Re-issues are ordinary.

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