amylin — 23 things I got wrong before I got it right
amylin — 23 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments.
Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories.
Sent a vial to Medutest because there was almost nothing on file for this compound. 97.8% against a claimed 97.0%, and I posted it because the log needs entries.
Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same receptor.
Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same recepto
Disagreeing with this line: that figure is from a combination arm and is being quoted as monotherapy.
Yes. The combination is where the interesting effect sizes are, and the monotherapy arms read very differently.
Is there any independent purity data on this compound that you have seen?
Is there any independent purity data on this compound that you have seen?
incretin_ivy is right that the evidence base here is thin. Conclusions should be held loosely.
That result is preclinical. Worth flagging, since the thread has been reading it as human data.
nausea profile in the combination trials is the thing to read carefully
Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.
Correcting myself upthread: I gave the 72-week figure and the paper reports 26 weeks.
The engineering problem was duration: native amylin is short-acting and aggregation-prone. A long-acting analogue suitable for weekly administration is what makes the combination clinically interesting.
read the combination arms separately from the monotherapy arms
read the combination arms separately from the monotherapy arms
This is the distinction that keeps this board honest — different axis, not a stronger version of the same one.
Right, and the tolerability data in the combination arms is the part worth reading properly rather than summarising.
read the combination arms separately from the monotherapy arms
Agreed, and the combination arms are where the interesting numbers actually live.
That is preclinical work and the thread is treating it as a human finding.
Kept a log purely because so few people are logging this one. It is one person and it is not data.
Monotherapy arm or combination arm?
Same view — long-acting is the engineering achievement here, and it is why the molecule exists at all.
Independent purity data on this compound is sparse compared with the older molecules, simply because far fewer members have paid for testing. Sparse data means wide uncertainty, not a verdict.
Agreed — it is an amylin analogue and importing intuitions from the incretin boards produces confident nonsense.
Which receptor family are you attributing that effect to?
do not assume the dosing intuitions from the GLP-1 boards transfer
Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.
What does the tolerability table in that paper actually say?
Agreed — it is an amylin analogue and importing intuitions from the incretin boards produces confident nonsense.
Adding the standing caveat — nothing here is approved standalone and research material is not for human use.
the co-agonism argument is about complementary mechanisms
Yes. Anyone reading this board should hold their conclusions loosely until phase 3 reports.
- 1Independent purity data on this compound is sparse compared with the older…8 comments in this branch · started by u/andres_dahlberg
- 2Is there any independent purity data on this compound that you have seen?6 comments in this branch · started by u/incretin_ivy