c/cagrilintide · created 4 Feb 2024
Long-acting amylin analog. CagriSema and the co-agonism question.
CagriSema trial ratios are fixed-dose, do not extrapolate to self-mixing — a position I have arrived at slowly and would like tested. Reading the trial literature on…
REDEFINE 1 — what cagri adds on top of sema. It is the sort of thing everyone half-believes and nobody writes down. Asked a question here that turned out to be based on…
The title is the argument: amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number. Here is the rest of it. Kept a log purely because…
The hill I will die on. Cagrilintide is a long-acting amylin analog and people keep filing it mentally as "more GLP-1". Amylin signalling and GLP-1 signalling converge…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsAmylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.
Certified reference materials for peptide identity and purity work.
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