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c/bloodwork·posted 1 year ago by u/a1c_arc

anyone else notice lipids kicking in around week 9

Explainer Receipts ×8 Well Actually ×3

anyone else notice lipids kicking in around week 9. Numbers below. Ask me the boring questions, they are the useful ones.

Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong.

Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.

Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.

3,339 up / 793 down81% upvoted59 commentsid 35vu6d18 May 2025

59 comments

19 in this archive, depth 5

best — the order this archive was captured in

u/kenji_kimani297 points·1 year ago

Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.

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u/liver_enzyme_lizMOD276 points·1 year ago

Standing reminder: nobody here interprets your results, and posts asking us to get a pointer to somebody who can.

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u/thermal_mass_tom215 points·1 year ago

That is a non-fasting value and the interval you are comparing it against is a fasting one.

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u/noor_hovland-32 points·1 year ago

ask whether the lab changed its assay between your two draws

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u/neha_rahimi1 point·1 year ago

baseline before you start is worth more than any later panel

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u/a1c_arcOPT2D150 points·1 year ago

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.

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u/blank_injection113 points·1 year ago

Is that the same assay, or did the lab change platforms?

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u/burned_once_twice94 points·1 year ago

assay method matters, especially between different labs

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u/gustav_cardoso150 points·1 year ago

How many weeks between the two measurements?

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u/mikkel_ogunleye51 points·1 year ago

This. Reference ranges are population intervals, not targets, and conflating them causes a lot of unnecessary alarm here.

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u/lipid_panel_larrybloodwork61 points·1 year ago

Time of day, fasting state, hydration and recent exercise all move common markers. Standardising the draw conditions is free and it removes most of the apparent variability.

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u/noor_cardoso19 points·1 year ago

fasting state and time of day change more than people expect

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u/ferran_halonen15 points·1 year ago

That comparison crosses two labs with different assays. The difference you are describing may be the method.

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u/elin_trevino105 points·1 year ago·edited

Not convinced by the attribution. Weight loss alone moves that marker and you have no way to separate the two.

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u/a1c_arcOPT2D0 points·1 year ago

Correcting my own comment: the two draws were 14 weeks apart, not the figure I gave earlier.

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u/tomas_kimani65 points·1 year ago

Have you taken this to whoever ordered it?

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u/customs_seizure_sid45 points·1 year ago

Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask better questions of somebody who can.

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u/bence_zamora46 points·1 year ago

Disagree with reading anything into that. One value, one morning, and you changed two other things in the same window.

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u/a1c_arcOPT2D0 points·1 year ago

Do you have a baseline from before you started?

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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