SURPASS

Right: SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. Hard…

how do you actually verify Zepbound. I am not trying to be the "source?" guy. I would just like a source. The step schedule question, answered properly, because it…

8th independent test on QST — 98.6% on a claimed 98.5%, and the trend is the interesting part. I will put the method line and the batch identifier up front because that…

SELECT: what the trials say vs what this community says — a position I have arrived at slowly and would like tested. Why comparing across trials almost never works,…

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about Mounjaro actually comes from Zepbound threads. On comparing…

Trying to get a straight answer on this: can we stop arguing about TRIUMPH until somebody posts a number. Compared myself to a trial mean for about six months before…

Filing this under things worth writing down: split one vial across Medutest and Janoshik — 99.3% and 98.7%. To save the first four comments: 99.3% and 98.7%.…

nobody warned me about muscle cramps and I would have liked the warning. Change my mind, genuinely — I have no stake in being right about this. Switching from…

SURPASS — 14 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments. Quoted a figure here confidently, got…

The title is the argument: SELECT: what the trials say vs what this community says. Here is the rest of it. Intention-to-treat analyses everybody randomised regardless…

how much of what we believe about endpoint actually comes from SELECT threads — that is what I am asking, and I have already read the wiki twice. On means, which this…

SURPASS — 22 things I got wrong before I got it right. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables and…

Slightly embarrassed to be asking this, but: how much of what we believe about Mounjaro actually comes from SURMOUNT threads. SURMOUNT-1 ran 72 weeks with the top arm…

Something I keep coming back to: SURPASS is doing more work than we give it credit for. Week 44 was the first time the scale moved after a five-week stall. I changed…

Something I keep coming back to: ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests. Quoted a figure here confidently, got asked…

proposal — a flair for FLOW posts. Nothing about this affects the ranking maths, before anyone asks. The registered protocol is public. Comparing the registered primary…

small win: Mounjaro stopped being a problem at week 66. Posting the boring middle of the process, because the internet is full of the start and the end and nothing…

Posting this as a discussion rather than a claim: REDEFINE 1 and what CagriSema actually adds over sema alone. Compared myself to a trial mean for about six months…

Reporting in. is it normal to get food noise at week 85. Research-use-only material is not approved for human use. Anything in this thread about how a research vial…

the FLOW rule is doing its job and people should stop complaining. This affects how posts get sorted and removed, so it belongs in the open. The discontinuation numbers…

"tirz is stronger than sema" needs a comparator dose or it means nothing. Making the case below, and I expect to lose some of it in the comments. Came off sema and onto…

is it normal to get constipation at week 87, and the part I actually want to talk about is at the bottom. Came off sema and onto tirz with a two-week gap. The first…

anyone else notice GIP kicking in around week 81, logged the same way every week so the comparison is at least internally fair. Sulphur burps for the first eight days…

Posting this as a discussion rather than a claim: STEP 1 vs SURMOUNT-1 side by side, with the caveats. Compared myself to a trial mean for about six months before…