is it normal to get constipation at week 87
is it normal to get constipation at week 87, and the part I actually want to talk about is at the bottom.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Week 68 was the first time the scale moved after a five-week stall. I changed nothing in that window.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
week 3 is early to draw any conclusion at all
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
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What step are you on and how long have you been there?
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
hold the dose that works, the ladder is not a leaderboard
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
a lot of people plateau nicely at 10mg and never need 15
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
the appetite effect is blunter than sema, in a good way, most weeks
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 2 is not a fair reading.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
24kg over 59 weeks, never went past 10mg, and sulphur burps stayed mild the whole way. Posting because the loud threads are all 15mg.
- 1Push back: "gentler than sema" is a population statement. Plenty of people…6 comments in this branch · started by u/vito_chowdhury