my ApoB moved and I cannot work out whether SURPASS is why
my ApoB moved and I cannot work out whether SURPASS is why. Change my mind, genuinely — I have no stake in being right about this.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Week 60 was the first time the scale moved after a five-week stall. I changed nothing in that window.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Pen or vial? The step sizes available differ and it changes this answer.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
week 5 is early to draw any conclusion at all
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
hold the dose that works, the ladder is not a leaderboard
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
sulphur burps are the signature complaint and they are not dangerous
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 40 is not a fair reading.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
if 7.5 is working, 10 is not automatically better
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
the four-week step schedule is the label, not folklore
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Correction to my own post above — I said 10mg and I have been on 5mg since the spring. Same argument, wrong number.
- 1Weekly dosing again, half-life in the same neighbourhood as sema, so a step…7 comments in this branch · started by u/certified_reference
- 2SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…6 comments in this branch · started by u/zaid_balogun