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c/tirzepatide·submitted 2 years ago by u/alcohol_aversion

my ApoB moved and I cannot work out whether SURPASS is why

Discussionbranch of 7 comments

my ApoB moved and I cannot work out whether SURPASS is why. Change my mind, genuinely — I have no stake in being right about this. Switching from semaglutide, since three people asked in this thread alone. There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s…

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7 comments, started 2 years ago
u/certified_referenceQC250 points·2 years ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/georgi_chowdhury107 points·2 years ago

sulphur burps are the signature complaint and they are not dangerous

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u/zeynep_zielinski100 points·2 years ago

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 40 is not a fair reading.

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u/matias_salgado25 points·2 years ago·edited

Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.

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u/two_mil_or_one19 points·2 years ago

if 7.5 is working, 10 is not automatically better

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u/certified_referenceQC49 points·2 years ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/hub_opssite staff175 points·2 years ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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