is it normal to get early fullness at week 69
Check-in as promised in the title: is it normal to get early fullness at week 69.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Not sure that follows.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
sulphur burps are the signature complaint and they are not dangerous
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your reflux pattern is a guess.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
if 7.5 is working, 10 is not automatically better
7kg over 17 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the loud threads are all 15mg.
[deleted]
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 65 is not a fair reading.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
the four-week step schedule is the label, not folklore
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
week 9 is early to draw any conclusion at all
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state.
Saving this one. It is the clearest statement of the stall problem I have read here.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
pens and vials are the same molecule, the price is the difference
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
- 1Held 7.5 for five months. Everyone kept asking when I was going to 10. The…10 comments in this branch · started by u/piotr_nascimento
- 2The four-week interval in the label is a minimum. Nothing about the…6 comments in this branch · started by u/matias_salgado