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c/tirzepatide·submitted 2 years ago by u/aksel_kjaer

is it normal to get early fullness at week 69

Titrationbranch of 6 comments

Check-in as promised in the title: is it normal to get early fullness at week 69. Switching from semaglutide, since three people asked in this thread alone. There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that…

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6 comments, started 2 years ago
u/matias_salgado383 points·2 years ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/tarek_lokken87 points·2 years ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/aksel_kjaerOP52 points·2 years ago

Not sure that follows.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/quiet_moderatorMOD218 points·2 years ago

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.

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u/throwaway_wl2026100 points·2 years ago

sulphur burps are the signature complaint and they are not dangerous

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u/incretin_ivypharmacology498 points·2 years ago·edited

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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