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c/tapering·posted 13 days ago by u/patient_labslip_log

[Regain] appetite came back over five weeks, here is the timeline

Regain

The title is the argument: appetite came back over five weeks, here is the timeline. Here is the rest of it.

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

Ask me anything specific. Anything general I will probably get wrong.

242 up / 68 down78% upvoted24 commentsid qyujgj17 Jul 2026

24 comments

15 in this archive, depth 2

best — the order this archive was captured in

u/coldchain_karencold chain31 points·13 days ago

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

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u/zeynep_villalobos21 points·12 days ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/patient_labslip_logOP21 points·12 days ago

the withdrawal data is unambiguous and it is not about willpower

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u/adaeze_brandt16 points·13 days ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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u/taper_off_tabithaMOD14 points·12 days ago

Left up. It is honest about the reason for stopping and about the timeline.

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u/quarter_dose_queenlow and slow11 points·12 days ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/zeynep_weiss17 points·12 days ago

interval stretching is the most commonly described approach here

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u/laila_delgado4 points·12 days ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/arne_amankwah0 points·11 days ago

Push back: that is a taper schedule aimed at another member and this board does not host those.

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[deleted]1 point·11 days ago

[deleted]

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u/maintenance_mode_maxmaintenance7 points·12 days ago

coming back later is allowed and it is common

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u/aleksi_lehtinen4 points·12 days ago·edited

Disagree with the framing. Regain is the documented outcome after discontinuation; calling it a personal failure is both wrong and corrosive.

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u/source_or_silence5 points·12 days ago

a fortnight of nothing is not evidence that you are fine

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u/ferran_krastev4 points·12 days ago

What are you planning to watch for, and over what period?

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u/ismael_varga2 points·11 days ago

Do you have a written baseline from before you started changing anything?

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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