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c/tapering·posted 8 months ago by u/zeynep_weiss

stalled for 12 weeks at 1.0mg and I refuse to panic this time

Trial Data

Posting this as a discussion rather than a claim: stalled for 12 weeks at 1.0mg and I refuse to panic this time.

Figures up front so nobody has to dig: 12 weeks and 1.0mg.

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

128 up / 6 down96% upvoted18 commentsid ip6n572 Nov 2025

18 comments

14 in this archive, depth 3

best — the order this archive was captured in

u/maren_baptista24 points·8 months ago

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

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u/naomi_ekstrom16 points·8 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/yara_bakken11 points·8 months ago

I would not treat appetite returning as a sign of doing it wrong. It is the expected sequence.

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u/zeynep_ndiaye3 points·8 months ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/zeynep_ndiaye1 point·8 months ago

Cosigning that cost and supply are legitimate reasons. Most of the stopping threads here are one of those two.

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u/taper_off_tabithaMOD9 points·8 months ago

Pointing the clinical part of this at somebody qualified. The experience part can stay here.

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u/border_paperwork2 points·8 months ago

Preparing to stop, as described by people here who have done it.

Write down where you are first: dose, date, weight, waist, and an honest note about how appetite feels. That page is what makes the following six months interpretable rather than a fog of impressions.

Decide in advance what you are watching for and over what period — appetite in the first month, weight over three, and a specific threshold at which you would want to revisit the decision. Have the conversation with a clinician before rather than after.

None of that is a schedule. It is a way of arriving at whatever happens next with information rather than with a vague sense of how it is going.

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u/cormac_roos1 point·8 months ago

appetite comes back before the weight does

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u/preservative_free_p4 points·8 months ago

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

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u/zeynep_zielinski4 points·8 months ago

stopping is a plan, not an event

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u/aleksi_lehtinen2 points·8 months ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/marta_marchand2 points·8 months ago

write down where you are before you change anything

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u/chidi_roos1 point·8 months ago

Have you had the conversation with a clinician yet?

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u/viktor_kirchner1 point·8 months ago

stopping abruptly and stopping gradually are different experiences

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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