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c/tapering·posted 3 months ago by u/ahmed_cardoso

stalled for 11 weeks at 15mg and I refuse to panic this time

Trial Data Cold Box ×2 The Quiet One ×3

stalled for 11 weeks at 15mg and I refuse to panic this time. It is the sort of thing everyone half-believes and nobody writes down.

11 weeks and 15mg — those are the numbers, and they are the ones I am willing to defend.

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

Tell me where this is wrong. That is the useful part of posting it.

2,029 up / 200 down91% upvoted56 commentsid 1kfrqz17 Apr 2026

56 comments

21 in this archive, depth 4

best — the order this archive was captured in

u/ferran_krastev335 points·3 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/maintenance_mode_maxmaintenance140 points·3 months ago

have the conversation with a clinician before, not after

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u/fabio_lehtinen48 points·3 months ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/micro_bump_mick21 points·3 months ago

decide what you are watching for before you stop

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u/maintenance_mode_maxMOD114 points·3 months ago

Edited a comment framing regain as a moral failure. The documented outcome is not a character verdict.

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u/ines_boateng95 points·3 months ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/vikram_ferreira91 points·3 months ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/priya_weiss85 points·3 months ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

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u/ahmed_okafor0 points·3 months ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rath

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/ahmed_cardosoOP1 point·3 months ago·edited

Wrote down where I was before changing anything. That single page made the following six months interpretable.

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u/controversial_only1 point·3 months ago

stopping abruptly and stopping gradually are different experiences

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u/lift_heavy_thingsresistance training65 points·3 months ago

Stopped for cost reasons. Appetite came back at about week 10, well before the scale moved, exactly as this board said it would.

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u/taper_off_tabitha40 points·3 months ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/patient_labslip_log-16 points·3 months ago

Same. A quiet fortnight after stopping tells you very little; the interesting part starts later.

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u/janek_ferrari1 point·3 months ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/marta_marchand17 points·3 months ago

Agreed that returning later is common and it is treated here as ordinary rather than as a defeat.

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u/zeynep_ndiaye4 points·3 months ago

write down where you are before you change anything

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u/naomi_ekstrom59 points·3 months ago

regain is the expected outcome and framing it as failure helps nobody

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u/elin_varga43 points·3 months ago

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

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u/controversial_only37 points·3 months ago·edited

What are you planning to watch for, and over what period?

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u/arne_restrepo25 points·3 months ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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