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c/t2dglp1·posted 5 months ago by u/rui_only_ro

[Question] how do you actually verify glycaemic control

Question Cold Box ×5

Slightly embarrassed to be asking this, but: how do you actually verify glycaemic control.

My A1c moved and it turned out to have nothing to do with glucose at all.

The order things move in, since nobody explains it and it worries people.

Postprandial excursions generally respond earliest. Variability tends to narrow before the average does, which is visible on a sensor and invisible on a lab result. Fasting glucose is often the laggard, and A1c — being a three-month average — is the last thing to reflect anything.

So a month in which the sensor looks better and the fasting number has not moved is the ordinary sequence, not a contradiction. Knowing that in advance would have saved me a quarter of unnecessary worry, which is why it is worth writing down.

Assumed the weight endpoints from the obesity trials applied to my situation. They are different programmes.

I will update this if the picture changes rather than quietly leaving it up.

737 up / 104 down88% upvoted16 commentsid yccl4x23 Feb 2026

16 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/gentle_correctionMOD84 points·5 months ago

Pointing this at whoever manages your diabetes. We compare experiences here; we do not adjust regimens.

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u/joaquin_stanescu50 points·5 months ago

Certain conditions affect A1c independently of glycaemia. If a result looks inconsistent with the sensor data, that is a question for whoever manages your care rather than for this board.

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u/kian_solberg75 points·5 months ago

A1c, CGM, or fingersticks — which are we discussing?

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u/priya_weiss35 points·5 months ago

postprandial excursions are where most of the improvement shows up first

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u/fasting_insulin_f37 points·5 months ago

sensor accuracy varies and the first day of a sensor is the worst

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u/hassan_ostergaard-7 points·5 months ago

Panicked over a first-day sensor reading and rebuilt my week around it. It was the sensor.

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u/britt_abubakar1 point·5 months ago

That A1c change is inside the assay’s variability and the interval you measured over is too short.

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u/rui_only_roOP0 points·5 months ago

How long between the two A1c measurements?

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u/arne_amankwah1 point·5 months ago

Push back: one sensor reading is not a data point worth acting on, especially in the first day of wear.

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u/not_my_main_nm30 points·5 months ago

Variability dropped before the average did, which was visible on the sensor and invisible on the lab result.

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u/hana_lehtinen21 points·5 months ago

Cosigning that postprandial excursions improve first and the fasting number is the laggard.

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u/tomas_kimani17 points·5 months ago

Yes — time in range tells you about variability, which the average deliberately hides.

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u/ingrid_correia5 points·5 months ago

the diabetes trials report different endpoints from the obesity ones

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u/graph_it_gary11 points·5 months ago

Postprandial excursions flattened out first and the fasting number took months to follow. Nobody had told me to expect that order.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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