[Discussion] MASH is doing more work than we give it credit for
MASH is doing more work than we give it credit for. Change my mind, genuinely — I have no stake in being right about this. Spent an evening on the histology scoring system and understood the trial literature far better afterwards. Sent a vial to PeptideMeter because there was nothing on file. 99.2% against a claimed…
Read the phase 2 hepatic paper properly and the endpoint definitions were more interesting than the headline response rate.
Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost nothing.
Yes — nothing containing this is approved anywhere, which is the first fact and usually the last one mentioned.
Bought small because the evidence base is early. That is the only defensible position I could construct.
glucagon agonism and energy expenditure is the mechanistic thread
Cosigning on the glucagon arm. It is the mechanistic thread that connects the hepatic and the metabolic effects.
That is an escalation schedule for an unapproved compound and this board does not host those.
Careful with the mechanism claim. Glucagon agonism is plausible as an explanation and it has not been isolated as the operative one.