[Question] how do you actually verify biopsy
Asking properly rather than in a comment on somebody else’s thread: how do you actually verify biopsy. Went slowly because everything published describes a deliberate escalation. That is the extent of what I will say about it. Asked here what the difference was between the imaging and biopsy endpoints and got a…
Not convinced. Imaging-based fat fraction is not the same as a histological response and the paper is explicit about that.
Assumed the weight numbers were the point and was corrected. They are secondary to what this is being developed for.
independent testing on this compound is very thin
Which phase and which arm are you quoting?
What this compound is actually being developed for, since the boards treat it as a weight-loss molecule with a footnote.
It is a dual GLP-1 and glucagon receptor agonist, and the glucagon arm links to hepatic fat and energy expenditure. The headline programme is metabolic liver disease, with endpoints scored on biopsy rather than on a scale.
That matters for how the data should be read. A histological response rate in a biopsy-confirmed population answers a very different question from a mean weight change in an obesity trial, and quoting one in place of the other — which happens in nearly every thread here — is not a comparison.
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glucagon agonism and energy expenditure is the mechanistic thread