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Single comment threadYou are looking at one branch of genuine question about MASH that I am slightly embarrassed to ask — 55 comments in the full submission. View in context.
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c/survodutide·submitted 1 year ago by u/joaquin_ivaturi

genuine question about MASH that I am slightly embarrassed to ask

Paperbranch of 6 comments

genuine question about MASH that I am slightly embarrassed to ask. I would rather ask a basic question now than get this wrong quietly for two months. Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer. Bought small because the evidence base is early. That…

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6 comments, started 1 year ago
u/elin_tamm34 points·1 year ago

Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.

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u/incretin_ivyMOD24 points·1 year ago·edited

Removed the escalation schedule. Unapproved compound, no protocols for other members, no exceptions.

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u/sofia_ferreira8 points·1 year ago

MASH endpoints are histological, which is a much harder bar

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u/hugo_bergstrom2 points·1 year ago

biopsy-confirmed is not the same as imaging-suggested

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u/cold_chromatogram_only1 point·1 year ago

dual GLP-1 and glucagon agonist, and the glucagon arm is the story

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u/isabela_nilsen1 point·1 year ago·edited

dual GLP-1 and glucagon agonist, and the glucagon arm is the story

Disagreeing with this bit: that number comes from a different programme with a different population.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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