stalled for 8 weeks at 1.7mg and I refuse to panic this time
stalled for 8 weeks at 1.7mg and I refuse to panic this time. Making the case below, and I expect to lose some of it in the comments. Since the title puts numbers in the shop window: 8 weeks and 1.7mg. Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer.…
Sent a vial to VendorInvestigate because there was nothing on file. 97.9% against a claimed 97.0%. First entry for this compound in my own log.
Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis without worsening of steatohepatitis. Both are harder to achieve and to interpret than an imaging surrogate.
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Push back: the evidence here is phase 2, in a specific population, and it does not support a general ranking.
Push back: the evidence here is phase 2, in a specific population, and it does not support a general ranking.
This is the framing the board needs. It is a hepatic programme first.
Same. Very thin independent data on this one, which should make everybody here more tentative than they are.
Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis wit
Disagreeing with this bit: that number comes from a different programme with a different population.
read the histology endpoint definitions before quoting a response rate
I would not read across from the obesity programmes. Different population, different endpoint, different question.