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c/sideeffects·posted 2 years ago by u/blank_injection

tried reflux for 11 weeks. here is what happened.

Question

Thinking out loud about this: tried reflux for 11 weeks. here is what happened.

11 weeks — those are the numbers, and they are the ones I am willing to defend.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

182 up / 278 down40% upvoted15 commentsid 1j2k8y21 Nov 2023

15 comments

15 in this archive, depth 3

best — the order this archive was captured in

u/iman_falk6 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 66 probably does not, and that is worth saying to a clinician rather than to us.

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u/liv_okafor3 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve.

iman_falk is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/sanne_laurent2 points·2 years ago

fatigue plus low intake is usually just low intake

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u/liv_vukovic-26 points·2 years ago

What is intake actually looking like — fibre and water especially?

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u/blank_injectionOP9 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/laila_delgado12 points·2 years ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/ipamorelin_i6 points·2 years ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/nausea_notesMOD3 points·2 years ago·edited

Flair set to Question. Also the standing reminder that nothing on this board is medical advice.

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u/constipation_clubside effects5 points·2 years ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/clara_weiss2 points·2 years ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/adnan_karlsen2 points·2 years ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/lina_dziedzic2 points·2 years ago

if it is severe or persistent that is a clinician question, not a board question

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u/elin_lundgren2 points·2 years ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/rafael_ostergaard1 point·2 years ago

the food noise going quiet is the effect people came for, and sulphur burps are the toll for the first fortnight

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u/blank_injectionOP1 point·2 years ago

How long after a step up did this start?

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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