[Results] 37 weeks, 6kg, and weekly dosing was the hard part
37 weeks, 6kg, and weekly dosing was the hard part. Full detail below, and I have tried to keep the editorialising out of it.
Numbers, in the order they matter: 37 weeks and 6kg.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
sema is weekly for a reason, the half-life does the smoothing
week 52 plateau is the most predictable thing in this entire board
sema is weekly for a reason, the half-life does the smoothing
bilal_osei is describing the standard shape here and it matches the trial data better than most anecdotes do.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
the ladder exists because the gut needs the time, not because the pharmacy likes paperwork
nausea that arrives on day two and fades by day four is the standard shape
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
stalling at 2.4mg is information, not a verdict
Does fatigue track the day after the shot, or is it there all week?
staying at 2.4mg for an extra month is a legitimate plan
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
This matches me almost exactly, right down to the early fullness showing up on the second day and being gone by the fourth.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
the first four weeks are a tolerance check, not a weight-loss phase
the scale is the least sensitive instrument you own
Correcting myself from earlier in the thread: I said week 6 and it was week 14. Same shape, wrong number.
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
- 1The escalation schedule in the trials existed to keep people on the drug. It…6 comments in this branch · started by u/hassan_ostergaard