[Results] 37 weeks, 6kg, and weekly dosing was the hard part
37 weeks, 6kg, and weekly dosing was the hard part. Full detail below, and I have tried to keep the editorialising out of it. Numbers, in the order they matter: 37 weeks and 6kg. Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.…
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
sema is weekly for a reason, the half-life does the smoothing
week 52 plateau is the most predictable thing in this entire board
sema is weekly for a reason, the half-life does the smoothing
bilal_osei is describing the standard shape here and it matches the trial data better than most anecdotes do.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
the ladder exists because the gut needs the time, not because the pharmacy likes paperwork