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c/reconstitution·submitted 3 days ago by u/katrin_marchetti

[PSA] your bac water is fine, your fridge door is not

PSAbranch of 7 comments

your bac water is fine, your fridge door is not. That is the post. The justification is underneath. Asked SGN what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know. Started reconstituting everything to a round concentration and the six-in-the-morning…

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7 comments, started 2 days ago
u/yusuf_achebe97 points·2 days ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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u/clara_weiss46 points·2 days ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose. Change the water volume until the numbers land on whole units.

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u/signe_grimaldi0 points·2 days ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose.

Right, and the arithmetic behind it: 5mg in 1mL is 5mg/mL, so 5mg is 100 units.

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u/soren_zamora44 points·2 days ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions fo

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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u/katrin_marchettiOP26 points·2 days ago

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

soren_zamora has the units point exactly right. They are a volume on the barrel and nothing else.

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u/kenji_kimani13 points·2 days ago

The lyophilised cake displaces a small volume, so the true concentration is very slightly lower than the arithmetic suggests. It is a fraction of a percent and it is dwarfed by fill tolerance.

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u/viktor_erdogan10 points·1 days ago

Careful — that arithmetic is wrong. 15mg in 2mL is 7.5mg/mL, so 0.75mg draws to 10 units, not what you wrote.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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